Trial intelligence / Profile preview

LOTIS-5: loncastuximab tesirine + rituximab versus R-GemOx in relapsed or refractory diffuse large B-cell lymphoma

jRCT2011230028Phase 3Active, not recruiting

Sponsor
Mitsubishi Tanabe Pharma Corporation
Start
Oct 2023
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
01

Overview

Phase 3, randomised, open-label trial of loncastuximab tesirine, rituximab, gemcitabine and oxaliplatin in diffuse large B-cell lymphoma (DLBCL) and large-cell lymphoma (2 arms), sponsored by Mitsubishi Tanabe Pharma Corporation. Primary endpoint: Progression-free survival. Started Oct 2023; status: active, not recruiting.

02

Drugs

loncastuximab tesirinerituximabgemcitabineoxaliplatin
03

Conditions

diffuse large B-cell lymphoma (DLBCL)large-cell lymphoma

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