Trial intelligence / Profile preview

Phase 1/2 Study of BLU-451 in Advanced Cancers with EGFR Exon 20 Insertion Mutations

jRCT2031220390Phase 2Completed

Sponsor
Blueprint Medicines
Start
Jan 2023
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
01

Overview

Phase 2, open-label, single-arm trial of BLU-451 in non-small cell lung cancer (NSCLC) and Nonhematologic neoplasms, sponsored by Blueprint Medicines. Primary endpoints: Maximum tolerated dose (MTD) of BLU-451 (Phase 1), Recommended Phase 2 dose (RP2D) of BLU-451 (Phase 1) and 2 more. Started Jan 2023; status: completed.

02

Drugs

BLU-451
03

Conditions

non-small cell lung cancer (NSCLC)Nonhematologic neoplasms

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