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Petosemtamab plus pembrolizumab versus pembrolizumab for first-line recurrent or metastatic PD-L1-positive head and neck squamous cell carcinoma
jRCT2031240724Phase 3Active, not recruiting
- Sponsor
- Genmab
- Start
- Mar 2025
- Modality
- Immune Checkpoint Inhibitors → Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
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Overview
Phase 3, randomised, open-label trial in head and neck squamous cell carcinoma (HNSCC) comparing Petosemtamab plus pembrolizumab with Pembrolizumab monotherapy (2 arms). Primary endpoints: Objective response rate and Overall survival. Started Mar 2025; status: active, not recruiting.
02
Drugs
petosemtamabpembrolizumab
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Conditions
head and neck squamous cell carcinoma (HNSCC)
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