Trial intelligence / Profile preview

ACACIA-HCM: Aficamten in Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

jRCT2031250066Phase 3Active, not recruiting

Sponsor
Cytokinetics
Start
Jun 2025
Modality
Small Molecules
01

Overview

Phase 3, randomised, double-blind trial in hypertrophic cardiomyopathy (HCM) comparing Aficamten with Placebo (2 arms). Primary endpoints: Change in Kansas City Cardiomyopathy Questionnaire - Clinical Summary Score (KCCQ-CSS) and Change in peak oxygen uptake (pVO2). Started Jun 2025; status: active, not recruiting.

02

Drugs

aficamten
03

Conditions

hypertrophic cardiomyopathy (HCM)

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