Trial intelligence / Profile preview

TNT with FLOT, pembrolizumab, and short-course radiotherapy for resectable esophagogastric junction adenocarcinoma

jRCT2031250089Phase 2Recruiting

Sponsor
Merck & Co.
Start
Aug 2025
Modality
Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, open-label, single-arm trial of pembrolizumab, docetaxel, oxaliplatin, folinic acid and fluorouracil in gastroesophageal junction adenocarcinoma, sponsored by Merck & Co. Primary endpoint: 3-year event-free survival rate. Started Aug 2025; status: recruiting.

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Drugs

pembrolizumabdocetaxeloxaliplatinfolinic acidfluorouracil
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Conditions

gastroesophageal junction adenocarcinoma

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