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PARTHENON: AZD4956 as monotherapy and in combination with saruparib in homologous recombination deficient solid tumours

jRCT2031260176Phase 1Recruiting

Sponsor
AstraZeneca
Start
Jul 2026
Modality
Small Molecules
01

Overview

Phase 1, open-label trial of AZD4956 and saruparib in solid neoplasms, breast cancer, ovarian cancer and 4 more (3 arms), sponsored by AstraZeneca. Primary endpoints: Number of participants with adverse events and serious adverse events, Progression-free survival (PFS) and 1 more. Started Jul 2026; status: recruiting.

02

Drugs

AZD4956saruparib
03

Conditions

solid neoplasmsbreast cancerovarian cancerfallopian tube cancer (PFTC)primary peritoneal cancer (PPC)

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