Trial intelligence / Profile preview

Perioperative ivonescimab plus FLOT for resectable esophageal, esophagogastric junction, or gastric cancer

jRCT2031260610Phase 2Not yet recruiting

Sponsor
National Cancer Center Hospital East
Start
Jan 2027
Modality
Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, open-label, single-arm trial of ivonescimab, fluorouracil, folinic acid, oxaliplatin and docetaxel in Esophageal Squamous Cell Carcinoma (ESCC), gastroesophageal junction adenocarcinoma and gastric adenocarcinoma, sponsored by National Cancer Center Hospital East. Primary endpoint: Major pathological response rate by central pathological assessment. Planned start Jan 2027; status: not yet recruiting.

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Drugs

ivonescimabfluorouracilfolinic acidoxaliplatindocetaxel
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Conditions

Esophageal Squamous Cell Carcinoma (ESCC)gastroesophageal junction adenocarcinomagastric adenocarcinoma

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