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GRAPE Trial: Gemcitabine, Cisplatin, Nivolumab plus Tamibarotene in First-Line Urothelial Carcinoma

jRCT2041250017Recruiting

Sponsor
Japan Agency for Medical Research and Development
Start
Apr 2025
Modality
Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Countries
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Overview

Open-label, single-arm trial of tamibarotene, nivolumab, gemcitabine and cisplatin in transitional cell carcinoma (TCC), sponsored by Japan Agency for Medical Research and Development. Primary endpoint: Response rate (RR). Started Apr 2025; status: recruiting.

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Drugs

tamibarotenenivolumabgemcitabinecisplatin
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Conditions

transitional cell carcinoma (TCC)

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