Trial intelligence / Profile preview

OLYMPIA-3: Odronextamab + CHOP vs R-CHOP in previously untreated DLBCL

jRCT2041260115Phase 3Not yet recruiting

Sponsor
Regeneron Pharmaceuticals
Start
Oct 2026
Modality
T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
01

Overview

Phase 3, randomised, open-label trial of odronextamab in diffuse large B-cell lymphoma (DLBCL) (2 arms), sponsored by Regeneron Pharmaceuticals. Primary endpoints: Incidence of dose-limiting toxicities (DLTs) in Part 1, Incidence of treatment-emergent adverse events (TEAEs) in Part 1 and 2 more. Planned start Oct 2026; status: not yet recruiting.

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Drugs

odronextamab
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Conditions

diffuse large B-cell lymphoma (DLBCL)

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