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REPLACE: Regorafenib + Pembrolizumab vs TACE/TARE in Intermediate-stage HCC (Beyond Up-to-7)

jRCT2051240126Phase 3Suspended

Sponsor
Translational Research In Oncology
Start
Sep 2024
Modality
Immune Checkpoint Inhibitors → Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes, Small Molecules
01

Overview

Phase 3, randomised, open-label trial of regorafenib and pembrolizumab in hepatocellular carcinoma (HCC) (2 arms), sponsored by Translational Research In Oncology. Primary endpoint: Progression-free survival (PFS) by mRECIST (Investigator-assessed). Started Sep 2024; status: suspended.

02

Drugs

regorafenibpembrolizumab
03

Conditions

hepatocellular carcinoma (HCC)

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