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Nivolumab + relatlimab with platinum-pemetrexed chemotherapy versus pembrolizumab with platinum-pemetrexed chemotherapy in first-line PD-L1-positive non-squamous advanced NSCLC

jRCT2051240173Phase 3Recruiting

Sponsor
Bristol Myers Squibb
Start
Jan 2025
Modality
Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
01

Overview

Phase 3, randomised, open-label trial of nivolumab, relatlimab, pembrolizumab, pemetrexed, carboplatin and 1 more in Non-small cell lung cancer (NS-NSCLC) (2 arms), sponsored by Bristol Myers Squibb. Primary endpoint: Overall survival in participants with PD-L1 1% to 49%. Started Jan 2025; status: recruiting.

02

Drugs

nivolumabrelatlimabpembrolizumabpemetrexedcarboplatin
03

Conditions

Non-small cell lung cancer (NS-NSCLC)

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