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First-in-human intrathecal S230815 in paediatric KCNT1-related developmental and epileptic encephalopathy
jRCT2051260035Phase 2Recruiting
- Sponsor
- Servier
- Start
- Apr 2026
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
01
Overview
Phase 2, open-label, single-arm trial of nivolumab + ipilimumab in epileptic encephalopathy, Malignant Migrating Partial Seizures of Infancy (MMPSI) and early infantile epileptic encephalopathy (EIEE), sponsored by Servier. Primary endpoint: Incidence and severity of adverse events. Started Apr 2026; status: recruiting.
02
Drugs
nivolumab + ipilimumab
03
Conditions
epileptic encephalopathyMalignant Migrating Partial Seizures of Infancy (MMPSI)early infantile epileptic encephalopathy (EIEE)
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