Trial intelligence / Profile preview

TITAN: Phase I Open-label Study of AZD5492 in Autoimmune Diseases

jRCT2071250048Phase 1Recruiting

Sponsor
AstraZeneca
Start
Aug 2025
Modality
Trispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
01

Overview

Phase 1, open-label trial of AZD5492 in systemic lupus erythematosus (SLE), Autoimmune Myopathies, polymyositis (PM) and 2 more (2 arms), sponsored by AstraZeneca. Primary endpoint: Safety and tolerability of AZD5492. Started Aug 2025; status: recruiting.

02

Drugs

AZD5492
03

Conditions

systemic lupus erythematosus (SLE)Autoimmune Myopathiespolymyositis (PM)dermatomyositis (DM)rheumatoid arthritis (RA)

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