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LEAP-006: Pembrolizumab + platinum/pemetrexed chemotherapy with or without lenvatinib in first-line metastatic nonsquamous NSCLC

jRCT2080224588Phase 3Completed

Sponsor
Merck & Co.
Start
Mar 2019
Modality
Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
01

Overview

Phase 3, randomised, double-blind trial of pembrolizumab, lenvatinib, pemetrexed, carboplatin and cisplatin in non-small cell lung cancer (NSCLC) (2 arms), sponsored by Merck & Co. Primary endpoints: Overall Survival (OS) and Progression-Free Survival (PFS). Started Mar 2019; status: completed.

02

Drugs

pembrolizumablenvatinibpemetrexedcarboplatincisplatin
03

Conditions

non-small cell lung cancer (NSCLC)

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