Trial intelligence / Profile preview

Phase II single-arm trial of topical diclofenac to prevent fruquintinib-induced hand-foot syndrome

jRCTs031250630Phase 2Recruiting

Start
May 2026
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, open-label, single-arm trial of diclofenac and fruquintinib in Erythrodysesthesia syndrome (PPE). Primary endpoint: Incidence of Grade 2 or higher hand-foot syndrome within 2 months. Started May 2026; status: recruiting.

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Drugs

diclofenacfruquintinib
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Conditions

Erythrodysesthesia syndrome (PPE)

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