Trial intelligence / Profile preview

JPLSG-AML-D24 risk-stratified azacitidine-based chemotherapy study in pediatric myeloid leukemia with Down syndrome

jRCTs041250031Phase 2Recruiting

Sponsor
Japan Agency for Medical Research and Development
Start
Jun 2025
Modality
DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, open-label trial of azacitidine, cytarabine, etoposide and pirarubicin in myeloid leukemia associated with Down syndrome (ML-DS) (4 arms), sponsored by Japan Agency for Medical Research and Development. Primary endpoint: 3-year event-free survival. Started Jun 2025; status: recruiting.

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Drugs

azacitidinecytarabineetoposidepirarubicin
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Conditions

myeloid leukemia associated with Down syndrome (ML-DS)

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