Trial intelligence / Profile preview

NOMINATE-2: Non-operative Management after Chemoradiotherapy plus Sandwich mFOLFOXIRI in Locally Advanced Rectal Cancer

jRCTs051250182Phase 2Recruiting

Start
Jan 2026
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
Countries
1
01

Overview

Phase 2, open-label, single-arm trial of oxaliplatin, irinotecan, fluorouracil, folinic acid and capecitabine in rectal cancer. Primary endpoint: Primary: Proportion of patients achieving cCR or near-cCR and undergoing non-operative management. Started Jan 2026; status: recruiting.

02

Drugs

oxaliplatinirinotecanfluorouracilfolinic acidcapecitabine
03

Conditions

rectal cancer

Beyond the preview

Go deeper on jRCTs051250182.

Study design, results and competitive context are available in the Gosset platform where reported.

Study design & results

Available in the Gosset platform where reported.

Competitive context

Available in the Gosset platform where reported.

Bring the full picture into focus.

See how Gosset can support your research on jRCTs051250182.

Gosset Free

Get started with Gosset.

Enter your corporate email.

Work email preferred.

Book a call