Trial intelligence / Profile preview

Phase 2 open-label multicenter study of bezuclastinib in advanced systemic mastocytosis

MOH_2023-10-20_012995Phase 2Not yet recruiting

Sponsor
Cogent Biosciences
Start
Oct 2023
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
Countries
1
01

Overview

Phase 2, randomised, open-label trial of bezuclastinib in systemic mastocytosis (SM), Aggressive Systemic Mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN) and 1 more (7 arms), sponsored by Cogent Biosciences. Primary endpoints: Dose optimization, Dose confirmation and 1 more. Planned start Oct 2023; status: not yet recruiting.

02

Drugs

bezuclastinib
03

Conditions

systemic mastocytosis (SM)Aggressive Systemic Mastocytosis (ASM)systemic mastocytosis with associated hematological neoplasm (SM-AHN)mast cell leukemia (MCL)

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