Trial intelligence / Profile preview

KEYMAKER-U04 sub-study 04D: MK-3120 + enfortumab vedotin + pembrolizumab in first-line advanced/metastatic urothelial carcinoma

MOH_2025-12-02_015510Phase 2Recruiting

Sponsor
Merck & Co.
Start
Nov 2025
Modality
Immune Checkpoint Inhibitors → Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Countries
1
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Overview

Phase 2, open-label trial of MK-3120, enfortumab vedotin and pembrolizumab in transitional cell carcinoma (TCC) (3 arms), sponsored by Merck & Co. Primary endpoints: Objective response rate, Safety and 1 more. Started Nov 2025; status: recruiting.

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Drugs

MK-3120enfortumab vedotinpembrolizumab
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Conditions

transitional cell carcinoma (TCC)

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