Trial intelligence / Profile preview

KEYMAKER-U01 sub-study MK3475-01F in previously treated KRAS G12C-mutant nonsquamous NSCLC

MOH_2026-02-01_015631Phase 2Not yet recruiting

Sponsor
Merck & Co.
Start
Jan 2026
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Countries
1
01

Overview

Phase 2, open-label trial of calderasib, patritumab deruxtecan, sacituzumab tirumotecan and cetuximab in non-small cell lung cancer (NSCLC) (3 arms), sponsored by Merck & Co. Primary endpoints: Safety, Tolerability and 1 more. Planned start Jan 2026; status: not yet recruiting.

02

Drugs

calderasibpatritumab deruxtecansacituzumab tirumotecancetuximab
03

Conditions

non-small cell lung cancer (NSCLC)

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