Trial intelligence / Profile preview

Phase 3 randomized double-blind trial of PF-08634404 plus mFOLFOX6 versus bevacizumab plus mFOLFOX6 in previously untreated metastatic colorectal cancer

MOH_2026-02-16_015661Phase 3Not yet recruiting

Sponsor
Pfizer
Start
Feb 2026
Modality
Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
Countries
1
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Overview

Phase 3, randomised, double-blind trial of PF-08634404, bevacizumab, folinic acid, fluorouracil and oxaliplatin in colorectal cancer (CRC) and colorectal adenocarcinoma (2 arms), sponsored by Pfizer. Primary endpoints: Progression-free survival and Overall survival. Planned start Feb 2026; status: not yet recruiting.

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Drugs

PF-08634404bevacizumabfolinic acidfluorouraciloxaliplatin
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Conditions

colorectal cancer (CRC)colorectal adenocarcinoma

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