Trial intelligence / Profile preview

Dabrafenib and Trametinib in BRAF V600E Positive Erdheim Chester Disease

NCT02281760Phase 2Completed

Sponsor
National Human Genome Research Institute
Start
Nov 2014
Primary completion
Aug 2018
Modality
Small Molecules
Countries
1
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Overview

Phase 2, open-label, single-arm trial of dabrafenib + trametinib and trametinib in Erdheim-Chester disease (ECD), sponsored by National Human Genome Research Institute. Primary endpoints: Number of Participants With Partial Response at 24 months, Number of Participants With Adverse Events at 24 months and 1 more. Started Nov 2014; status: completed.

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Drugs

dabrafenib + trametinibtrametinib
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Conditions

Erdheim-Chester disease (ECD)

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