Sanaria PfSPZ Challenge with Pyrimethamine Chemoprophylaxis

Phase 1, open-label trial of PfSPZ Challenge in malaria (4 arms), sponsored by National Institute of Allergy and Infectious Diseases. Primary endpoints: Incidence and severity of local and systemic adverse events (AEs) and serious adverse events (SAEs) and P. falciparum blood stage infection defined as detection of P. falciparum parasites by sensitive research qRT-PCR. Started Jul 2015; status: completed.