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The Effect of Carbonic Anhydrase Inhibitors on the Pulmonary System Response to Muscle Fatigue
NCT02758470Phase 4Completed
- Sponsor
- University of British Columbia
- Start
- Nov 2016
- Primary completion
- Jun 2017
- Modality
- Small Molecules
- Countries
- 1
01
Overview
Phase 4, randomised trial in hypoxia comparing Acetazolamide, Methazolamide and Placebo (3 arms). Primary endpoints: Change in trans-diaphragmatic pressure generation to supramaximal phrenic nerve stimulation following inspiratory threshold loading at 30 months and Change in plantar flexor muscle group torque generation to supramaximal tibial nerve stimulation following an isometric loading protocol at 30 months. Started Nov 2016; status: completed.
02
Drugs
acetazolamidemethazolamide
03
Conditions
hypoxia
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