Trial intelligence / Profile preview

Adrenergic Contribution to Glucose Counterregulation in Islet Transplantation

NCT03079921Phase 1Completed

Sponsor
University of Pennsylvania
Start
Jan 2017
Primary completion
Apr 2019
Modality
Small Molecules
Countries
1
01

Overview

Phase 1, randomised, double-blind trial of phentolamine and propranolol in type 1 diabetes mellitus (T1D) and hypoglycemia (5 arms), sponsored by University of Pennsylvania. Primary endpoints: C-Peptide Suppression During Hyperinsulinemia Euglycemia and Glucagon Activation During Hyperinsulinemia Hypoglycemia. Started Jan 2017; status: completed.

02

Drugs

phentolaminepropranolol
03

Conditions

type 1 diabetes mellitus (T1D)hypoglycemia

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