Trial intelligence / Profile preview

NCI-COG Pediatric MATCH Screening Protocol

NCT03155620Phase 2Active, not recruiting

Sponsor
National Cancer Institute
Start
Jul 2017
Primary completion
Mar 2025
Modality
Fragment-Derived Small Molecules, Reversible Covalent Inhibitors, Bivalent/Multivalent Binders
Countries
4
01

Overview

Phase 2, open-label trial of larotrectinib, erdafitinib, tazemetostat, samotolisib, selumetinib and 8 more in solid tumor, non-Hodgkin lymphoma (NHL) and histiocytic disorder (13 arms), sponsored by National Cancer Institute. Primary endpoint: Proportion of Pediatric Patients Whose Advanced Tumors Have Pathway Alterations That Can be Targeted by Select Anti-cancer Drugs up to 2 years. Started Jul 2017; status: active, not recruiting.

02

Drugs

larotrectiniberdafitinibtazemetostatsamotolisibselumetinib
03

Conditions

solid tumornon-Hodgkin lymphoma (NHL)histiocytic disorder

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