Rifampicin Effect on Clazosentan PK in Healthy Males

Phase 1, randomised, double-blind trial of clazosentan in aneurysmal subarachnoid hemorrhage (SAH) (2 arms), sponsored by Idorsia. Primary endpoints: Area under the concentration-time curve from zero to time t of the last measured concentration above the limit of quantification at 24 hours, Area under the concentration-time curve from zero to infinity at 24 hours and 5 more. Started Jul 2018; status: completed.