Trial intelligence / Profile preview

Lorlatinib PK in Advanced Cancer with Hepatic Impairment

NCT03726333Phase 1Terminated

Sponsor
Pfizer
Start
Jan 2020
Primary completion
Jul 2021
Modality
Fragment-Derived Small Molecules, Allosteric Modulators, Orthosteric Ligands
Countries
1
01

Overview

Phase 1, open-label trial of lorlatinib in solid tumor and lymphoma (5 arms), sponsored by Pfizer. Primary endpoints: Area Under Plasma Lorlatinib Concentration-Time Curve From Time 0 to Dosing Interval of 24 Hours and Observed Maximal Plasma Concentration. Started Jan 2020; status: terminated.

02

Drugs

lorlatinib
03

Conditions

solid tumorlymphoma

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