Trial intelligence / Profile preview

R21/Matrix-M and ME-TRAP Malaria Challenge Study

NCT03947190Phase 2Terminated

Sponsor
University of Oxford
Start
Aug 2022
Primary completion
Feb 2023
Modality
Viral Vector Vaccines, Recombinant Protein Vaccines
Countries
1
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Overview

Phase 2, randomised, open-label trial of R21/Matrix-M and ChAd63/MVA ME-TRAP in Falciparum malaria (PF) (4 arms), sponsored by University of Oxford. Primary endpoints: Occurrence of solicited local and systemic reactogenicity signs and symptoms, and unsolicited adverse events, Occurrence of P. falciparum parasitemia assessed by PCR and 1 more. Started Aug 2022; status: terminated.

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Drugs

R21/Matrix-MChAd63/MVA ME-TRAP
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Conditions

Falciparum malaria (PF)

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