Effect of Methacholine, Tiotropium, and Formoterol on Beta-receptors in Healthy Volunteers

Open-label trial of formoterol and tiotropium in chronic obstructive pulmonary disease (COPD) (2 arms), sponsored by Research Institute of Pulmonology. Primary endpoints: Change from baseline beta-receptor binding activity after inhalation of formoterol or tiotropium at 60 minutes and Change from baseline beta-receptor binding activity after challenge test with metacholine at 40 minutes. Status: unknown.