Trial intelligence / Profile preview

BrainChild-03: B7-H3 CAR T Cell Therapy for Pediatric CNS Tumors

NCT04185038Phase 1Recruiting

Sponsor
Seattle Children's
Start
Dec 2019
Primary completion
May 2027
Modality
CAR-T Cells
Countries
1
01

Overview

Phase 1, open-label trial of BCB-276 in diffuse intrinsic pontine glioma (DIPG), diffuse midline glioma (DMG) and central nervous system tumor (5 arms), sponsored by Seattle Children's. Primary endpoints: Safety defined by adverse events at 7 months and Feasibility of CAR T cell production and administration at 28 days. Started Dec 2019; status: recruiting.

02

Drugs

BCB-276
03

Conditions

diffuse intrinsic pontine glioma (DIPG)diffuse midline glioma (DMG)central nervous system tumor

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