Estradiol and Prolonged Exposure Therapy for PTSD

Phase 3, randomised, double-blind trial in post-traumatic stress disorder (PTSD) comparing Prolonged Exposure (PE) therapy with Estradiol with Prolonged Exposure (PE) therapy with Placebo (2 arms). Primary endpoints: Change in Amygdala Activation as Measured by Functional Magnetic Resonance Imaging (fMRI) Blood Oxygen Level Dependent (BOLD) Signal at Day 2, Change in Dorsal Anterior Cingulate Cortex (dACC) Activation as Measured by Functional Magnetic Resonance Imaging (fMRI) Blood Oxygen Level Dependent (BOLD) Signal at Day 2 and 2 more. Started Jun 2020; status: completed.