Trial intelligence / Profile preview

Immune and Targeted Combination Therapies in First Line Metastatic RCC (U03A)

NCT04626479Phase 2Completed

Sponsor
Merck & Co.
Start
Dec 2020
Primary completion
Aug 2026
Modality
Immune Checkpoint Inhibitors, Recombinant Proteins and Enzymes
Countries
14
01

Overview

Phase 2, randomised, open-label trial of pembrolizumab, lenvatinib, belzutifan, quavonlimab, favezelimab and 1 more in renal cell carcinoma (RCC) (5 arms), sponsored by Merck & Co. Primary endpoints: Dose-Limiting Toxicities at 21 days, Adverse Events at 43 months and 2 more. Started Dec 2020; status: completed.

02

Drugs

pembrolizumablenvatinibbelzutifanquavonlimabfavezelimab
03

Conditions

renal cell carcinoma (RCC)

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