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Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1
NCT04770155Phase 1Terminated
- Sponsor
- University of Mississippi Medical Center
- Start
- May 2021
- Primary completion
- Sep 2021
- Modality
- Nucleic Acid-Directed Small Molecules, Orthosteric Ligands
- Countries
- 1
01
Overview
Phase 1, randomised, double-blind trial of dietary nitrate, citrulline, sildenafil and bosentan in vascular dysfunction (8 arms), sponsored by University of Mississippi Medical Center. Primary endpoints: Flow-mediated Dilation at 4 hours, Reactive Hyperemia (Cuff Release) at 4 hours and 3 more. Started May 2021; status: terminated.
02
Drugs
dietary nitratecitrullinesildenafilbosentan
03
Conditions
vascular dysfunction
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