Trial intelligence / Profile preview

SMMART-ACT: Personalized Cancer Treatment

NCT05238831Phase 1Withdrawn

Sponsor
OHSU Knight Cancer Institute
Start
Jan 2023
Primary completion
May 2026
Modality
Irreversible Covalent Inhibitors, Antibody-Drug Conjugates (ADCs), Targeted Protein Degraders (TPDs)
01

Overview

Phase 1, open-label, single-arm trial of alectinib, alpelisib, anastrozole, atezolizumab, bevacizumab and 20 more in breast carcinoma, ovarian carcinoma, pancreatic carcinoma and 2 more, sponsored by OHSU Knight Cancer Institute. Primary endpoint: Proportion of participants who receive an ACT therapy based an ACT Tumor Board recommendation at 2 years. Planned start Jan 2023; status: withdrawn.

02

Drugs

alectinibalpelisibanastrozoleatezolizumabbevacizumab
03

Conditions

breast carcinomaovarian carcinomapancreatic carcinomaprostate carcinomasarcoma

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