Adjunctive EQU-001 for Uncontrolled Focal Onset Seizures

• EQU-001 60 mg

  Ivermectin 60 mg daily + Standard of Care ASMs

• EQU-001 20 mg

  Ivermectin 20 mg daily + Standard of Care ASMs

• Placebo

  Matching Placebo + Standard of Care ASMs

Primary

• Median percentage change in the overall number of countable observable seizuresWeek 1 to Week 16

Secondary

• Median percentage change in the overall number of countable observable seizuresWeek 5 to Week 16

• >= 50% responder ratesWeek 5 to Week 16

• Patient's Global Impression of ChangeWeek 6 to Week 16

• Percent (%) of subjects who are seizure freeWeek 5 to Week 16

• >= 70% and >= 90% response ratesWeek 5 to Week 16

• Patient weighted Quality of Life in Epilepsy (QOLIE 31-P) scale scoreWeek 6 to Week 16

• Number of adverse events (CTCAE grade 2 or higher)Week 1 to Week 16

• Columbia-Suicide Severity Rating ScaleWeek 1 to Week 16