Trial intelligence / Profile preview

TCRαβ/CD19 Depleted HSCT and Kidney Transplant

NCT05508009Phase 2Recruiting

Start
Jan 2023
Primary completion
Oct 2032
Modality
Stem Cell Therapies
Countries
1
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Overview

Phase 2, open-label trial of T-cell receptor alpha/beta and CD19 depleted hematopoietic stem cells in chronic kidney disease (CKD), kidney failure, Schimke immuno-osseous dysplasia (SIOD) and 3 more (4 cohorts). Primary endpoint: Number of patients who are able to discontinue immunosuppression post-KT. Started Jan 2023; status: recruiting.

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Drugs

T-cell receptor alpha/beta and CD19 depleted hematopoietic stem cells
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Conditions

chronic kidney disease (CKD)kidney failureSchimke immuno-osseous dysplasia (SIOD)focal segmental glomerulosclerosis (FSGS)cystinosis

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