Trial intelligence / Profile preview

AK104 in locally advanced rectal cancer

NCT05794750Phase 2

Key facts

Status
Not yet recruiting
Start
Apr 2023
Primary completion
Apr 2027
Sponsor
Jinjing (Beijing) Biotechnology
Modality
Bispecific Antibodies
Conditions
rectal cancer
01

Overview

Phase 2, open-label trial of cadonilimab in rectal cancer, sponsored by Jinjing (Beijing) Biotechnology. Planned start Apr 2023; status: not yet recruiting.

02

Design

Study design
Non-randomizedOpen-labelSingle group
03

Who it enrols

Patients aged 18-75 with stage II/III rectal adenocarcinoma, ECOG 0-1, and no prior immunotherapy or radiation.

04

Registry description

This study is a single-arm, open-label, multicenter clinical study to evaluate the efficacy and safety of preoperative short-course radiotherapy combined with AK104 and chemotherapy + TME surgery in patients with advanced rectal cancer.

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