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Investigation of Locus Coeruleus Function in Sustained Attention
NCT06041048Phase 4
Key facts
- Status
- Recruiting
- Start
- Oct 2023
- Primary completion
- Dec 2026
- Countries
- 1
- Sponsor
- University of California, Davis
- Modality
- Small Molecules
- Drugs
- modafinil
01
Overview
Phase 4, randomised, double-blind trial comparing Modafinil with Placebo (2 arms). Primary endpoint: Brain activity - BOLD response at 1 hour. Started Oct 2023; status: recruiting.
02
Design
2 arms- Study design
- RandomizedDouble-blind
Modafinil
Single oral dose (200 mg) of Modafinil
Placebo
Single oral dose of Placebo
03
Who it enrols
Healthy adults aged 18-60 without a history of psychosis, severe substance use disorder, specific cardiovascular conditions, or contraindications for MRI.
04
Endpoints
Primary
Brain activity - BOLD response
Secondary
Attention on Oddball and POP task
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