Trial intelligence / Profile preview

SLP mKRASvax, Balstilimab, and Botensilimab for Stage IV MMR-p Colorectal and Pancreatic Cancer

NCT06411691Phase 1Recruiting

Sponsor
Sidney Kimmel Comprehensive Cancer Center
Start
Nov 2024
Primary completion
Nov 2029
Modality
Antisense DNA, Vaccines & Immunotherapeutics, Small Interfering RNA (siRNA)
Countries
1
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Overview

Phase 1, open-label, single-arm trial of mKRASvax, balstilimab and botensilimab in colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC), sponsored by Sidney Kimmel Comprehensive Cancer Center. Primary endpoints: Progression-Free Survival at 4 months, Objective Response Rate at 3 years and 1 more. Started Nov 2024; status: recruiting.

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Drugs

mKRASvaxbalstilimabbotensilimab
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Conditions

colorectal cancer (CRC)pancreatic ductal adenocarcinoma (PDAC)

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