Trial intelligence / Profile preview

Zanubrutinib and Obinutuzumab in Previously Untreated CLL/SLL

NCT06544785Phase 2Recruiting

Sponsor
Fundación PETHEMA
Start
Sep 2024
Primary completion
May 2032
Modality
Fragment-Derived Small Molecules, Reversible Covalent Inhibitors, Bivalent/Multivalent Binders
Countries
1
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Overview

Phase 2, randomised, open-label trial in chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) comparing Arm Zanubrutinib+early Obinutuzumab with Arm Zanubutinib+late Obinutuzumab (2 arms). Primary endpoint: Rate of Complete Remission with undetectable Measurable Residual Disease at 7.5 years. Started Sep 2024; status: recruiting.

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Drugs

zanubrutinibobinutuzumab
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Conditions

chronic lymphocytic leukemia (CLL)small lymphocytic lymphoma (SLL)

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