Trial intelligence / Profile preview

Ketamine Mechanism of Action in Major Depressive Disorder

NCT06788249Phase 1Recruiting

Sponsor
University of Pennsylvania
Start
Apr 2026
Primary completion
Dec 2026
Modality
Small Molecules
Countries
1
01

Overview

Phase 1, open-label, single-arm trial of ketamine in major depressive disorder (MDD), sponsored by University of Pennsylvania. Primary endpoint: Glutamate Chemical Exchange Saturation Transfer imaging metrics at 9 hours. Started Apr 2026; status: recruiting.

02

Drugs

ketamine
03

Conditions

major depressive disorder (MDD)

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