Trial intelligence / Profile preview

GOAL Trial: Ammonia Lowering in Hyperammonemic ACLF

NCT06808009Not yet recruiting

Sponsor
Institute of Liver and Biliary Sciences
Start
Feb 2025
Primary completion
Feb 2026
Modality
Orthosteric Ligands, Metabolically Activated Prodrugs
Countries
1
01

Overview

Randomised, open-label trial of lactulose and rifaximin in acute-on-chronic liver failure (ACLF) (2 arms), sponsored by Institute of Liver and Biliary Sciences. Primary endpoint: Proportion of patients achieving composite endpoint target NH3 level < 79.5 mmol/L and/or Incidence of MALO at Day 7. Planned start Feb 2025; status: not yet recruiting.

02

Drugs

lactuloserifaximin
03

Conditions

acute-on-chronic liver failure (ACLF)

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