Trial intelligence / Profile preview

Donanemab and RG6289 in Autosomal-Dominant Alzheimer's Disease

NCT06996730Phase 3Recruiting

Sponsor
Banner Health
Start
Jul 2026
Primary completion
Jun 2030
Modality
Small Molecules, Recombinant Proteins and Enzymes, Monoclonal Antibodies
Countries
1
01

Overview

Phase 3, randomised, double-blind trial of donanemab and nivegacetor in Alzheimer's disease (AD) (6 arms), sponsored by Banner Health. Primary endpoints: Change in amyloid load as measured by centiloid (CL) [F18]Florbetapir-PET at 18 months and Maintenance of Low Levels of Brain Amyloid as Measured by centiloid (Cl) [F18]Florbetapir-PET up to 18 months. Started Jul 2026; status: recruiting.

02

Drugs

donanemabnivegacetor
03

Conditions

Alzheimer's disease (AD)

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