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NACRE-2: SCRT +/- FOLFOX4s in Elderly Patients with Locally Advanced Rectal Cancer

NCT07118800Phase 3Not yet recruiting

Sponsor
Unicancer
Start
Jul 2026
Primary completion
Dec 2030
Modality
DNA Intercalators/Alkylators, Orthosteric Ligands
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Overview

Phase 3, randomised, open-label trial of oxaliplatin, folinic acid and fluorouracil in rectal cancer (2 arms), sponsored by Unicancer. Primary endpoint: Total Mesorectal Excision-free survival at 2 years. Planned start Jul 2026; status: not yet recruiting.

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Drugs

oxaliplatinfolinic acidfluorouracil
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Conditions

rectal cancer

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