Trial intelligence / Profile preview

TACE Combined with Iparomlimab/Tuvonralimab and Bevacizumab for Unresectable HCC

NCT07128251Phase 2

Key facts

Status
Not yet recruiting
Start
Aug 2025
Primary completion
Jan 2028
Sponsor
The First Affiliated Hospital of USTC
Modality
Monoclonal Antibodies, Fc-Fusion Proteins
Conditions
hepatocellular carcinoma (HCC)
01

Overview

Phase 2, open-label, single-arm trial of iparomlimab + tuvonralimab in hepatocellular carcinoma (HCC), sponsored by The First Affiliated Hospital of USTC. Primary endpoint: Progression-Free Survival at 2 years. Planned start Aug 2025; status: not yet recruiting.

02

Design

1 arm
Study design
Non-randomizedOpen-labelSingle group
  • Experimental Group

    TACE combined with Iparomlimab and Tuvonralimab Injection and Bevacizumab Injection.

03

Who it enrols

Adult patients with unresectable, non-metastatic HCC, Child-Pugh A, ECOG 0-1, and no prior systemic or locoregional therapy.

04

Endpoints

Primary

  • Progression-Free Survival

Secondary

  • Objective Response Rate

  • Disease Control Rate

  • Overall Survival

  • Adverse Events

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