Trial intelligence / Profile preview

METTSEO in Metastatic Ewing Sarcoma

NCT07194044Phase 1Recruiting

Sponsor
Moffitt Cancer Center
Start
Feb 2026
Primary completion
Oct 2030
Modality
Monoclonal Antibodies, DNA Intercalators/Alkylators, Targeted Liposomes
Countries
1
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Overview

Phase 1, open-label, single-arm trial of vincristine sulfate liposome injection, pegylated liposomal doxorubicin, cyclophosphamide, ifosfamide, actinomycin D and 5 more in Ewing sarcoma and CIC-rearranged sarcoma, sponsored by Moffitt Cancer Center. Primary endpoints: Feasibility and Safety - Consolidation at 16 months and Feasibility and Safety - Maintenance at 16 months. Started Feb 2026; status: recruiting.

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Drugs

vincristine sulfate liposome injectionpegylated liposomal doxorubicincyclophosphamideifosfamideactinomycin D
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Conditions

Ewing sarcomaCIC-rearranged sarcoma

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