Trial intelligence / Profile preview

CASCADES: Semaglutide vs Dapagliflozin vs Metformin in CAD and Pre-diabetes

NCT07254572Phase 4Recruiting

Sponsor
National Institute of Cardiology
Start
Jul 2025
Primary completion
Aug 2029
Modality
Peptides, Recombinant Proteins and Enzymes, Small Molecules
Countries
1
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Overview

Phase 4, randomised, open-label trial of semaglutide and dapagliflozin in coronary artery disease (CAD) and prediabetes (3 arms), sponsored by National Institute of Cardiology. Primary endpoints: Effect of GLP-1 analogue treatment on coronary artery disease progression at 24 months and Effect of flozin treatment on the progression of coronary artery disease at 24 months. Started Jul 2025; status: recruiting.

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Drugs

semaglutidedapagliflozin
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Conditions

coronary artery disease (CAD)prediabetes

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