Trial intelligence / Profile preview

C-CAR168 in Refractory Central Nervous System Autoimmune Diseases

NCT07341828Phase 1Not yet recruiting

Sponsor
Huashan Hospital
Start
Feb 2026
Primary completion
Jun 2027
Modality
Gene Editing, Gene Silencing, CAR-T Cells
01

Overview

Phase 1, open-label, single-arm trial of C-CAR168 in multiple sclerosis (MS), Neuromyelitis Optica Spectrum Disorder (NMOSD), Autoimmune Encephalitis (AE) and 1 more, sponsored by Huashan Hospital. Primary endpoints: Incidence and severity of Adverse Events at 24 months and Subsequent recommended dose of C-CAR168 at 24 months. Planned start Feb 2026; status: not yet recruiting.

02

Drugs

C-CAR168
03

Conditions

multiple sclerosis (MS)Neuromyelitis Optica Spectrum Disorder (NMOSD)Autoimmune Encephalitis (AE)stiff person syndrome (SPS)

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