Trial intelligence / Profile preview

B7-H3 CAR T Cells in Children and Young Adults With Relapsed or Refractory Solid Tumors

NCT07358260Phase 1Recruiting

Start
Aug 2026
Primary completion
Dec 2029
Modality
Gene Editing, Gene Silencing, CAR-T Cells
Countries
1
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Overview

Phase 1, open-label, single-arm trial of B7-H3 UCAR-T in Pediatric solid tumor (PST) and neuroblastoma. Primary endpoints: Manufacturing Success Rate of Autologous B7-H3.CD28Z CART Cells at Day 0 and Maximum Tolerated Dose at 28 days. Started Aug 2026; status: recruiting.

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Drugs

B7-H3 UCAR-T
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Conditions

Pediatric solid tumor (PST)neuroblastoma

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